Journal of Animal Environmental Research
پژوهش های محیط زیست جانوری
Journalaer
Basic Sciences
http://journalaer.com
1
admin
3115-7904
10.22034/aer
fa
jalali
1404
5
1
gregorian
2025
8
1
1
2
online
1
fulltext
fa
تاثیر یک دوره هم افزایی تمرین شنا در آب گرم و سرد به همراه مصرف مکمل دارچین بر برخی شاخص های آپوپتوزی بافت قلب رت های دیابتی توسط استرپتوزوتوسین
Synergistic Effect of a Course of Swimming Training in Hot and Cold Water Along with the Consumption of Cinnamon Supplement on Apoptotic Indices of The Cardiac Tissue in Streptozotocin-Induced Diabetic Rats
تخصصي
Special
پژوهشي
Research
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">مقدمه: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">یافته ­های اخیر نشان داده است که فعالیت بدنی و استفاده از آنتی اکسیدان­ ها می ­توانند منجر به کاهش عواقب ناشی از بیماری دیابت گردند. مطالعه حاضر با هدف بررسی اثر هم ­افزایی یک دوره تمرین شنا در آب گرم و سرد و مکمل­ دهی با دارچین بر بیان شاخص ­های آپوپتوزی بافت قلب (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">Bax</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black"> و</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">Bcl-2</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">) در رت­ های دیابتی، صورت گرفت. </span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">مواد و روش</span></span></span></b><b><span dir="LTR" lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">‎</span></span></span></b><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">ها:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">مطالعه حاضر یک</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">تحقیق </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">بنیادی تجربی با </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">طرح پس آزمون همراه با گروه کنترل بود که روی </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">49 موش ماده نژاد اسپراگوداولی (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">Sprague Dawley</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">) بالغ صورت گرفت. </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">تعداد 7 سر موش به</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">عنوان گروه کنترل سالم </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">و </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">42 سر موش دیابتی شده در گروه­ های 1) کنترل دیابتی، 2) دیابتی تمرین شنا در دمای 5 درجه سانتی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گراد، 3) دیابتی و مصرف دارچین، 4) دیابتی و تمرین شنا در دمای 5 درجه سانتی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گراد و مصرف دارچین، 5) دیابتی تمرین شنا در دمای 36 درجه سانتی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گراد و 6) دیابتی و تمرین شنا در دمای 36 درجه سانتی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گراد و مصرف</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">دارچین قرار</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گرفتند. </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">تمرین شنا به</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">مدت 8 هفته در آب با دمای 5 و 36 درجه سانتی­ گراد صورت</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گرفت. </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">عصاره آبی دارچین با دوز 200 میلی</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گرم به ازای هر</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">کیلوگرم از وزن بدن</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">حیوانات به</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">صورت خوراکی تجویز شد.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black"> اندازه ­گیری </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">بیان ژن ­های </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">Bax</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">Bcl2</span></span></span><b> </b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">با استفاده از واکنش زنجیره ایی پلیمراز (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">Real time PCR</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">) صورت گرفت.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">نتایج: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">مصرف<b> </b>دارچین، تمرین شنا و ترکیب این دو مداخله بر میزان </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">ژن­ های</span></span></span><b> </b><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">BAX</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">و</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black"> BCL2 </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">بافت</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black"> قلب رت­های دیابتی شده اثر معنی ­دار</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">داشت.</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">میانگین بیان ژن</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">BAX</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گروه دیابتی+ تمرین در دمای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">سرد (0/03=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">؛</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">0/259-=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">MD</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">)،</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گروه دیابتی+</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">تمرین در آب گرم (0/001=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">؛ 0/875- =</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">MD</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">)، گروه دیابتی+ تمرین در دمای سرد+دارچین (0/001=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">؛ 1/291 =</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">MD</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">) و گروه دیابتی+ تمرین در</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">دمای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گرم+دارچین</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">(0/001=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">؛</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">1/673- =</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">MD</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">) کاهش معنی ­داری نسبت به</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">گروه</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">کنترل</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Baran""><span style="color:black">دیابتی داشت. </span></span></span></span></span></span></span></span><br>
<b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Baran""><span style="color:black">بحث و نتیجه ­گیری: </span></span></span></span></b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Baran""><span style="color:black">به</span></span></span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Baran""><span style="color:black">نظر می ­رسد که هشت ﻫﻔﺘﻪ ﺗﻤﺮﻳﻦ ﺗﻨﺎوﺑﻰ ﺷﺪﻳﺪ ﻣﻰﺗﻮاﻧﺪ با ﻛﺎﻫﺶ ﺑﻴﺎن ژن </span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span style="font-family:"Times New Roman",serif"><span style="color:black">BAX</span></span></span></span><span dir="RTL" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Baran""><span style="color:black"> و اﻓﺰاﻳﺶ ژن </span></span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span style="font-family:"Times New Roman",serif"><span style="color:black">BCL-2</span></span></span></span><span dir="RTL" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Baran""><span style="color:black"> در ﻣﻴﻮﻛﺎرد ﻣﻮش</span></span></span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span style="font-family:"B Baran""><span style="color:black">ﻫﺎی ﻣﺒﺘﻼ ﺑﻪ دﻳﺎﺑﺖ، آﭘﻮﭘﺘﻮز را در ﺑﻄﻦ ﭼﭗ ﻛﺎﻫﺶ داده و اﺣﺘﻤﺎﻻً ﻛﺎردﻳﻮﻣﻴﻮﭘﺎﺗﻰ دﻳﺎﺑﺘﻰ را ﺑﻬﺒﻮد ﺑﺨﺸﺪ.</span></span></span></span></div>
دارچین, دیابت, تمرین, شاخص های آپوپتوزی, موش صحرایی
87
94
http://journalaer.com/browse.php?a_code=A-10-2-75&slc_lang=fa&sid=1
Ali
Amani
علی
امانی
1003194753284600871
1003194753284600871
No
Rahmatullah
Khanmohammadi
رحمت اله
خانمحمدی
1003194753284600872
1003194753284600872
No
Seyedeh Ommolbanin
Ghasemian
سیده ام البنین
قاسمیان
ommolbanin.ghasemian@iau.ac.ir
1003194753284600873
1003194753284600873
Yes