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Effect of Morphine administration on content of short-chain fatty acid of human gut microbiota
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Mohammad Reza Barzegar   , Mohsen Zargar * , Seyed Davar Siadat , Farzam Vaziri , Razieh Nazari |
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Abstract: (824 Views) |
Introduction: In addition to mental and spiritual problems, drug addiction affects the addict’s physical health. The digestive system is a key body system that contains plenty of opioid receptors, which makes it vulnerable to these compounds.
Materials & Methods: The present study is an attempt to study the effects of morphine on short chain fatty acid levels produced by the intestine microbiota. 30 healthy individuals and 30 oral users of opium (for six years with a mean daily intake of 0.8 gr) were recruited. All the participants were men with a mean age of 40±3.9 years. The mean period of consuming drugs in the drug addicts was six years. After sampling feces of the participants, the level of fatty acids, including acetate, propionate, and butyrate were measured through gas chematography-flame ionization detection.
Results: The results indicated that compared to the healthy participants, the drug addict group had a significantly higher acetate (97.91 vs. 76.2), propionate (25.91 vs. 19.28), and butyrate (25.36 vs. 19.68) level (µm/g).
Conclusion: In general, the results indicated that consuming morphine can affect production of short chain fatty acids. This can be attributed to the changes in microbiota of the digestive system of the consumers. |
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| Keywords: Morphine, Drug addict, Feces, Microbiota, Fatty acid |
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Full-Text [PDF 568 kb]
(326 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2025/10/6 | Accepted: 2025/09/1 | Published: 2025/12/2
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