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Preliminary study of the effect of nandrolone decanoate on blood calcium metabolic index and its possible clinical complications in pre-fresh heavily pregnant cows
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Hessam Mahammad Davoudi   , Nasser Alidadi * , Saied Bokaie , Ali Rassouli |
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Abstract: (1096 Views) |
Introduction: The late pregnancy period can be considered one of the most critical and sensitive stages of life in dairy cows, and it is necessary to use modern prevention and treatment methods to help cows pass this dangerous period. The aim of this clinical trial is to investigate the possible clinical complications of administration of nandrolone decanoate, as an anabolic compound, in heavily pregnant cows and possible changes in blood calcium levels.
Materials & Methods: The study was conducted in an industrial cattle farm and on heavily pregnant cows. The number of 15 dairy cows that were clinically normal were randomly divided into three groups 1, 2 and 3. At the point of time three weeks before the estimated parturition, 4 ml of 0.89% sodium chloride solution was given to each of the pregnant cows to group 1, which was the control, and 50 and 100 mg nandrolone decanoate to groups 2 and 2, respectively. 3 was injected subcutaneously to groups 2 and 3, respectively. Simultaneously with status monitoring and daily clinical care, the amount of 10 ml of blood serum samples from all 15 cows in three stages just before the injection of sodium chloride solution to group 1 and nandrolone decanoate to groups 2 and 3, 10 days after the stage First, and 24 hours after parturition, it was taken to measure the amount of calcium.
Results: Clinically, during one year after the commencement of the study, the least abnormal problems and complications such as anorexia, decreased milk production or abortion were not observed in the cows that received nandrolone decanoate. The mean blood serum calcium showed a statistically significant (VHS) increase in group 3 compared to groups 1 and 2 (p<0.001).
Conclusion: As a conclusion, this clinical trial showed that nandrolone decanoate at prescribed doses did not cause any clinical complications in heavily pregnant cows expecting calving and produced very high statistically significant changes in mean blood calcium, which is used to clarify the dimensions and various aspects of these findings, it is necessary to carry out extensive and comprehensive supplementary research on heavy pregnant cows. |
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| Keywords: Transition period, Heavy pregnancy, Clinical complications, Dairy cow, Nandrolone, Metabolism |
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Full-Text [PDF 734 kb]
(370 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2025/08/23 | Accepted: 2025/10/2 | Published: 2025/10/2
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