1. 1. Simonin, M., Gueguen, G. and Strullu, M., 2019. Acute lymphoblastic leukaemias in children. Pediatric Health, Medicine and Therapeutics. 22: 96-107

2. 2. Hunger, S.P., Lu, X., Devidas, M., Camitta, B.M., Gaynon, P.S., Winick, N.J., Reaman, G.H. and Carroll, W.L., 2012. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group. Journal of clinical oncology. 30(14): 1663-1669. doi: 10.1200/JCO.2011.37.8018

3. 3. DuVall, A.S., Sheade, J., Anderson, D., Yates, S.J. and Stock, W., 2022. Updates in the Management of Relapsed and Refractory Acute Lymphoblastic Leukemia: An Urgent Plea for New Treatments Is Being Answered!. JCO Oncology Practice. 18(7): 479-487. doi: 10.1200/ OP.21.00843

4. 4. Lippitz, B.E., 2013. Cytokine patterns in patients with cancer: a systematic review. The lancet oncology. 14(6): e218-e228. doi: 10.1016/S1470-2045(12)70582-X

5. 5. Colombo, M.P. and Trinchieri, G., 2002. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine & growth factor reviews. 13(2): 155-168. doi: 10.1016/s13 59-6101(01)00032-6

6. 6. Leutenegger, C.M., Mislin, C.N., Sigrist, B., Ehrengruber, M.U., Hofmann-Lehmann, R. and Lutz, H., 1999. Quantitative real-time PCR for the measurement of feline cytokine mRNA. Veterinary immunology and immunopathology. 71(3-4): 291-305. doi: 10.1016/s0165-2427(99)00100-2

7. 7. Nolan, T., Hands, R.E. and Bustin, S.A., 2006. Quantification of mRNA using real-time RT-PCR. Nature protocols. 1(3): 1559-1582. doi: 10.1038/nprot.2006.236

8. 8. Chen, S.Y., Yang, X., Feng, W.L., Liao, J.F., Wang, L.N., Feng, L., Lin, Y.M., Ren, Q. and Zheng, G.G., 2015. Organ-specific microenvironment modifies diverse functional and phenotypic characteristics of leukemia-associated macrophages in mouse T cell acute lymphoblastic leukemia. The Journal of Immunology. 194(6): 2919-2929. doi: 10.4049/jimmunol.1400451

9. 9. Ma, J., Wu, D., Hu, X., Li, J., Cao, M. and Dong, W., 2017. Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: A meta-analysis. PloS one. 12(4): e0176463. doi: 10.1371/journal.pone.0176463

10. 10. Khaledi, M., Moradipoodeh, B., Moradi, R., Baghbadorani, M.A. and Mahdavinia, M., 2022. Antiproliferative and proapoptotic activities of Sea Cucumber H. Leucospilota extract on breast carcinoma cell line (SK-BR-3). Molecular Biology Reports. 49(2): 1191-1200. doi: 10.1007/s11033-021-06947-0

11. 11. Moghadasi, Z., 2017. In vitro study on cytotoxic effect of methanolic extract from carpet anemone tentacles against brain and colon cell lines. Journal of Animal Environment. 9(3): 379-384. (In Presian)

12. 12. Kim, S.K. and Pangestuti, R., 2011. Biological activities and potential health benefits of fucoxanthin derived from marine brown algae. Advances in food and nutrition research. 64: 111-128. doi: 10.1016/B978-0-12-387669-0. 00009-0

13. 13. Shahhosseini, S., Kordjazi, M., Ahmad Nasrollahi, S., Ojagh, S.M., Naeimifar, A. and Sharifian, S., 2020. Investigation of some antibacterial and antioxidant properties of brown algae aqueous extract (Sargassum tenerrimum) collected from the Persian Gulf coast. Journal of Animal Environment. 12(2): 411-418. (In Presian)

14. 14. Mandrekar, V.K., Gawas, U.B. and Majik, M.S., 2019. Brominated molecules from marine algae and their pharmacological importance. Studies in Natural Products Chemistry. 61: 461-490. doi: 10.1016/B978-0-444-641 83-0.00013-0

15. 15. Mahendran, S., Sankaralingam, S., Sethupathi, S.M., Kathiresan, D., Muthumani, M., Kousalya, L., Palpperumal, S. and Harinathan, B., 2022. Evaluation of antioxidant and cytotoxicity activities of polyphenol extracted from brown seaweed Sargassum tenerrimum biomass. Biomass Conversion and Biorefinery. 14: 1-7. doi: 10.1007/s13399-022-02301-x

16. 16. Masoudi, M., Khaledi, H., Archangi, B., Khodadadi, A., Dinarvand, G. and Mousavi, S.M., 2022. The effect of Sargassum tenerrimum seaweed extracts on VEGF gene expression in SW742 colorectal cancer cell line. Daneshvar Medicine. 30(3): 52-61. doi: 10.22070/ daneshmed.2022.15747.1169 (In Presian)

17. 17. Patra, S., Muthuraman, M.S., Prabhu, A.T.J., Priyadharshini, R.R. and Parthiban, S., 2015. Evaluation of antitumor and antioxidant activity of Sargassum tenerrimum against Ehrlich ascites carcinoma in mice. Asian Pacific Journal of Cancer Prevention. 16(3): 915-921. doi: 10.7314/apjcp.2015.16.3.915

18. 18. Yende, S.R., Harle, U.N. and Chaugule, B.B., 2014. Therapeutic potential and health benefits of Sargassum species. Pharmacognosy reviews. 8(15): 1-7. doi: 10.41 03/0973-7847.125514.

19. 19. Golfakhrabadi, F., Khaledi, M., Nazemi, M. and Safdarian, M., 2021. Isolation, identification, and HPTLC quantification of dehydrodeoxycholic acid from Persian gulf sponges. Journal of Pharmaceutical and Biomedical Analysis. 197: 113962. doi: 10.1016/j.jpba. 2021.113962

20. 20. Bellinger, E.G. and Sigee, D.C., 2015. Freshwater algae: identification, enumeration and use as bioindicators. 1st ed. USA: John Wiley & Sons.

21. 21. Guiry, M.D., 2021. AlgaeBase: A global database for algae. Current Science. 121(1): 10-11.

22. 22. Salem, D.M. and Ismail, M.M., 2022. Characterization of cellulose and cellulose nanofibers isolated from various seaweed species. The Egyptian Journal of Aquatic Research. 48(7): 307-313. doi: 10.1016/j.ejar.2021.11.001

23. 23. Vijayan, S.R., Santhiyagu, P., Ramasamy, R., Arivalagan, P., Kumar, G., Ethiraj, K. and Ramaswamy, B.R., 2016. Seaweeds: A resource for marine bionanotechnology. Enzyme and microbial technology. 95: 45-57. doi: 10.1016/j.enzmictec.2016.06. 009

24. 24. Kumar, P., Senthamilselvi, S. and Govindaraju, M., 2013. GC-MS profiling and antibacterial activity of Sargassum tenerrimum. Journal of pharmacy Research. 6(1): 88-92. doi: 10.1016/j.jopr.2012.11.019

25. 25. Barbarino, E. and Lourenço, S.O., 2005. An evaluation of methods for extraction and quantification of protein from marine macro-and microalgae. Journal of Applied Phycology. 17(5): 447-460. doi:10.1007/s10811-005-16 41-4

26. 26. Hellio, C., Berge, J.P., Beaupoil, C., Le Gal, Y. and Bourgougnon, N., 2002. Screening of marine algal extracts for anti-settlement activities against microalgae and macroalgae. Biofouling. 18(3): 205-215. doi: 10.108 0/08927010290010137

27. 27. Sourani, Z., Pourgheysari, B., Beshkar, P., Shirzad, H. and Shirzad, M., 2016. Gallic acid inhibits proliferation and induces apoptosis in lymphoblastic leukemia cell line (C121). Iranian journal of medical sciences. 41(6):

28. 525-530.

29. 28. Trinchieri, G., 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nature Reviews Immunology. 3(2): 133-146. doi: 10.1038/nri1001

30. 29. Nastala, C.L., Edington, H.D., McKinney, T.G., Tahara, H., Nalesnik, M.A., Brunda, M.J., Gately, M.K., Wolf, S.F., Schreiber, R.D. and Storkus, W.J., 1994. Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. Journal of immunology (Baltimore, Md.: 1950). 153(4): 1697-1706.

31. 30. Pegram, H.J., Purdon, T.J., Van Leeuwen, D.G., Curran, K.J., Giralt, S.A., Barker, J.N. and Brentjens, R.J., 2015. IL-12-secreting CD19-targeted cord blood-derived T cells for the immunotherapy of B-cell acute lymphoblastic leukemia. Leukemia. 29(2): 415-422. doi: 10.1038/leu.2014.215

32. 31. Boieri, M., Ulvmoen, A., Sudworth, A., Lendrem, C., Collin, M., Dickinson, A.M., Kveberg, L. and Inngjerdingen, M., 2017. IL-12, IL-15, and IL-18

33. pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo. Oncoimmunology. 6(3): e1274478. doi: 10.1080/ 2162402X.2016.1274478

34. 32. Cocco, C., Pistoia, V. and Airoldi, I., 2012. Anti leukemic properties of IL-12, IL-23 and IL-27: differences and similarities in the control of pediatric B acute lymphoblastic leukemia. Critical reviews in oncology/hematology. 83(3): 310-318. doi: 10.1016/j.

35. critrevonc.2011.11.006

36. 33. Vemulawada, C., Renavikar, P.S., Crawford, M.P., Steward-Tharp, S., Guo, H., Jian, Z. and Karandikar, N.J., 2022. Disruption of IFNγ, PRF1, GZMB, or LYST results in reduced suppressive function in human CD8+ T cells. The Journal of Immunology. 212(11): 1722-1372. doi: 10.4049/jimmunol.2300388

37. 34. Yang, L., Xie, X., Tu, Z., Fu, J., Xu, D. and Zhou, Y., 2021. The signal pathways and treatment of cytokine storm in COVID-19. Signal transduction and targeted therapy. 6(1): 255. doi: 10.1038/s41392-021-00679-0

38. 35. Neufeldt, C.J., Cerikan, B., Cortese, M., Frankish, J., Lee, J.Y., Plociennikowska, A., Heigwer, F., Prasad, V., Joecks, S., Burkart, S.S. and Zander, D.Y., 2022. SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB. Communications biology. 5(1): 45. doi: 10.1038/s42003-0 21-02983-5

39. 36. Wenji, K.Y., Rukmi, I. and Suprihadi, A., 2019. In vitro Antifungal Activity of Methanolic and Chloroform Mint Leaves (Mentha piperita L.) Extracts Against Candida albicans. Journal of Physics: Conference Series. 1217(1): 012136. doi: 10.1088/1742-6596/1217/1/01213 6

40. 37. Sarkar, S., Gayen, K. and Bhowmick, T.K., 2022. Green extraction of biomolecules from algae using subcritical and supercritical fluids. Biomass Conversion and Biorefinery. 15: 21603-21625. doi: 10.1007/s13399-0 22-02309-3

41. 38. Karimzadeh, K. and Zahmatkesh, A., 2021. Phytochemical screening, antioxidant potential, and cytotoxic effects of different extracts of red algae (Laurencia snyderiae) on HT29 cells. Research in Pharmaceutical Sciences. 16(4): 400-413. doi: 10.4103/ 1735-5362.319578

42. 39. Truong, D.H., Nguyen, D.H., Ta, N.T.A., Bui, A.V., Do, T.H. and Nguyen, H.C., 2019. Evaluation of the use of different solvents for phytochemical constituents, antioxidants, and in vitro anti-inflammatory activities of Severinia buxifolia. Journal of food quality. 1-9. https:// doi.org/10.1155/2019/8178294

43. 40. Abbas, M., Saeed, F., Anjum, F.M., Afzaal, M., Tufail, T., Bashir, M.S., Ishtiaq, A., Hussain, S. and Suleria, H.A.R., 2017. Natural polyphenols: An overview. International Journal of Food Properties. 20(8): 1689-1699. https://doi.org/10.1080/10942912.2016.1220393

44. 41. Chu, L.L., Zhou, J., Dhakal, D. and Sohng, J.K., 2021. Recent Advances in Application of Synthetic Biology for Production of Bioactive Compounds. Frontiers in Bioengineering and Biotechnology. 9: 819475. https://

45. doi.org/10.3389/fbioe.2021.819475

46. 42. Somasundaram, S.N., Shanmugam, S., Subramanian, B. and Jaganathan, R., 2016. Cytotoxic effect of fucoidan extracted from Sargassum cinereum on colon cancer cell line HCT-15. International journal of biological macromolecules. 91: 1215-1223. doi: 10.1016/ j.ijbiomac.2016.06.084

47. 43. Ashayerizadeh, O., Dastar, B. and Pourashouri, P., 2020. Study of antioxidant and antibacterial activities of depolymerized fucoidans extracted from Sargassum tenerrimum. International journal of biological macromolecules. 151: 1259-1266. doi: 10.1016/j.

48. ijbiomac.2019.10.172

49. 44. Vasanthi, C., Appa Rao, V., Narendra Babu, R., Sriram, P. and Karunakaran, R., 2020. In‐vitro antioxidant activities of aqueous and alcoholic extracts of Sargassum species-Indian brown seaweed. Journal of Food Processing and Preservation. 44(11): e14877.

50. 45. Chitari, S., Dias, P.E. and Barros, U., 2018. Report On The Identification Of Alkaloids From Sargassum Tenerrimum. 40(2):1-6.

51. 46. Waghmode, A.V., Narayankar, C.U., Nimbalkar, M.S. and Gaikwad, D.K., 2019. Exploration of fucoxanthin and astaxanthin in macro alga (Sargassum sp.) by high performance liquid chromatography. Indian Hydrobiol. 18: 40-49.