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Investigating the antifungal effects ofhoney royal jellyin form nano and raw on Aspergillus flavus
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Elham Rezvannejad *   , Maryam Fayazi , Batool Sadeghi |
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Abstract: (438 Views) |
Introduction: Due to the increasing resistance of pathogenic bacteria and fungi to common antibiotics, it is important to find natural antimicrobial agents as alternative drugs. Aspergillus flavus is one of the most important fungi producing aflatoxin. In this research, the antifungal effects of royal jelly and its nanocomposite derivatives on Aspergillus flavus were studied.
Materials & Methods: To carry out this research, royal jelly sample was collected from bee farm in Kerman province and extracted in the laboratory. Then, Aspergillus flavus was cultured in a special environment and was affected by different dilutions of royal jelly extracts, sepiolite/royal jelly nanocomposites, and sepiolite/silver nitrate/royal jelly. Finally, the MIC and MFC of the samples and disk diffusion tests were determined. The obtained data were analyzed by SAS 9.1 software.
Result: The results of this research showed that although extracts of royal jelly and its nano compounds had less antifungal properties compared to the antibiotic used against Aspergillus flavus (P<0.01). But they have had a significant effect on the inhibition and lethality of Aspergillus flavus. So that royal jelly in crude form and nanocomposite at a concentration of 400mg/ml had inhibitory and lethal properties on the target fungus. Also, the sepiolite/silver nitrate/royal jelly nanocomposite extract had slightly but significantly more antifungal effect than the crude extract (P<0.01).
Conclusion: Therefore, it can be seen that royal jelly can be used as a natural antifungal, especially in nano form. |
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| Keywords: Low-risk drug, Inhibitory effects, Aspergillus flavus, Honey bee, Nanocomposite |
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Full-Text [PDF 944 kb]
(157 Downloads)
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Type of Study: Review |
Subject:
Special
Received: 2026/01/4 | Accepted: 2026/01/30 | Published: 2026/03/1
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